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Pregnant women warned about ACE1 inhibitor
Some of the most commonly used medicines for high blood pressure are drugs called ACE inhibitors. Doctors have given these drugs to patients for twenty-five years. A government study in the United States found that the use almost doubled between 1995 and 2000.
Doctors have known for years that women should not take ACE inhibitors during the last six months of pregnancy. The medicine can injure the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a new study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders.2 The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.
The researchers say they found no increased risk in women who took other blood pressure medicines during the first three months. Researchers at Vanderbilt University in Tennessee and Boston University did the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to women who took ACE inhibitors during the first three months of their pregnancies. Eighteen of the babies, or almost nine percent, had major disorders.
ACE inhibitors are often given to patients with diabetes. But diabetes during pregnancy can result in birth defects.5 So the study did not include any women known to be diabetic. ACE inhibitors suppress a protein called angiotensin-converting enzyme, or ACE. This enzyme produces a chemical in the body that makes blood passages narrow. The drugs increase the flow of blood so pressure is reduced.
New drugs are tested on pregnant animals to see if they might cause birth defects in humans. But experts say these tests are not always dependable. The United States Food and Drug Administration6 helped pay for the study. The F.D.A. says women who might become pregnant should talk with their doctor about other ways to treat high blood pressure.
詞匯:
pregnant adj. 懷孕的
inhibitor n. 抑制劑
pregnancy n. 懷孕
diabetes n. 糖尿病
diabetic adj. 糖尿病的 n. 糖尿病患者
suppress vt. 抑制
dependable adj. 可靠的
注釋:
1. ACE (angiotensin-converting enzyme):血管緊張肽轉(zhuǎn)化酶
2. birth disorders:先天性疾病
3. The study shows that, compared to others, their babies were almost three times as likely to be born with major problems. 這項(xiàng)研究表明,如果與其他嬰兒相比,這些嬰兒在出生時(shí)患大病的可能性幾乎是他們的三倍。compare to在美國(guó)英語(yǔ)中也有 compared with(與...相比)的意思。另外,problem在醫(yī)學(xué)文獻(xiàn)中常常用來(lái)指疾病。
4. New England Journal of Medicine:新英格蘭醫(yī)藥雜志。New England 是美國(guó)東北六州 ( Maine, Vermont, New Hampshire, Massachusetts, Rhode Island 和 Connecticut )的總稱。
5 birth defect ( = congenital defect):先天性缺陷,先天性缺損
6. United States Food and Drug Administration (FDA):美國(guó)食品與藥品管理局
練習(xí):
1. Paragraph 2
2. Paragraph 3
3. Paragraph 4
4. Paragraph 5
A Effects of ACE and ACE inhibitors
B Wide use of ACE inhibitors
C How to deal with high blood pressure in pregnant women
D Damage to pregnant women's future babies
E Suggestions on stopping the use of ACE inhibitors
F Relative safety for women during the first three months of pregnancies
5. FDA suggests that pregnant women with high blood pressure should consult .
6. ACE inhibitors are not recommended .
7. Evidence showed only a small percentage of babies suffered major disorders .
8. ACE is a risk factor to our body .
A that may cause our blood vessels to become more and more narrow
B for pregnant women to take during their last six months of pregnancies
C that their likelihood to suffer major problems is two times higher than other babies
D with their doctors about how to treat their problems
E because diabetes during pregnancy may sometimes lead to birth defects
F though their mothers took ACE inhibitors during their first three months of pregnancies
答案與解析:
1. 分析文章標(biāo)題: Pregnant(懷孕的) women warned about/of (被警告...)ACE (血管緊張肽轉(zhuǎn)化酶)inhibitor(抑制劑)
文章主題詞:pregnant women, warn, ACE inhibitor
2. 分析小標(biāo)題被選項(xiàng):
A Effects (影響)of ACE and ACE inhibitors(抑制劑)
B Wide(廣泛的) use (使用)of ACE inhibitors
C How to deal with (處理,應(yīng)對(duì))high blood pressure (高血壓)in pregnant women
D Damage to(對(duì)...的損害) pregnant women's future(未來(lái)的) babies(嬰兒)
E Suggestions on (關(guān)于...的建議)stopping(停止) the use of ACE inhibitors
F Relative(相對(duì)的, 有關(guān)系的) safety(安全) for women during(在...期間) the first three months of pregnancies (懷孕)
所有的被選項(xiàng)都直接或間接地涉及到了文章主題詞, 因此這些選項(xiàng)成為答案的可能性均較大。
1. 解答概括大意題:
A Effects (影響)of ACE and ACE inhibitors(抑制劑)
B Wide(廣泛的) use (使用)of ACE inhibitors
C How to deal with (應(yīng)對(duì))high blood pressure (高血壓)in pregnant women
D Damage to(對(duì)...的損害) pregnant women's future(未來(lái)的) babies(嬰兒)
E Suggestions on (關(guān)于...的建議)stopping(停止) the use of ACE inhibitors
F Relative(相對(duì)的) safety(安全) for women during(在...期間) the first three months of pregnancies (懷孕)
1. Paragraph 2
Doctors have known (已經(jīng)知道)for years that women should not take(服用) ACE inhibitors during(在...期間) the last (最后的, 最近的)six months of pregnancy. The medicine(藥品) can injure(傷害) the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a new study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders.2 The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.
1.D baby連同它的詞義相關(guān)詞共出現(xiàn)了4次,而且是貫穿全段出現(xiàn),因此baby是段落主題詞,由此判斷D可能是答案。段落開(kāi)頭的語(yǔ)句與D內(nèi)容一致,因此進(jìn)一步確認(rèn)D是答案。 第二段說(shuō)的是孕婦在孕期最后六個(gè)月服用ACE抑制劑會(huì)給未來(lái)嬰兒帶來(lái)傷害,嬰兒患大病的可能性幾乎是其他嬰兒的三倍,包括大腦和神經(jīng)系統(tǒng)發(fā)育缺陷及心臟出現(xiàn)空洞等。
A Effects (影響)of ACE and ACE inhibitors(抑制劑)
B Wide(廣泛的) use (使用)of ACE inhibitors
C How to deal with (應(yīng)對(duì))high blood pressure (高血壓)in pregnant women
E Suggestions on (關(guān)于...的建議)stopping(停止) the use of ACE inhibitors
F Relative(相對(duì)的, 有關(guān)系的) safety(安全) for women during(在...期間) the first three months of pregnancies (懷孕)
2. Paragraph 3
The researchers say (說(shuō))they found(發(fā)現(xiàn)) no increased(增加的) risk(風(fēng)險(xiǎn)) in women who took(服用) other blood pressure(血壓) medicines(藥) during the first three months. Researchers at Vanderbilt University in Tennessee and Boston University did the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to (由...生出)women who took(服用) ACE inhibitors during the first three months of their pregnancies(懷孕). Eighteen of the babies, or(即) almost nine percent, had major (主要的,嚴(yán)重的)disorders(紊亂).
1. F 段落段首句及段尾部分的句子均表明:服用的ACE的孕婦生下的孩子大部分沒(méi)有什么嚴(yán)重的影響,因此F是答案。第三段說(shuō)患高血壓的孕婦在孕期頭三個(gè)月服用其它降壓藥,她們的危險(xiǎn)性并沒(méi)有增加;即使服用ACE抑制劑,其嬰兒也只有大約9%患大病。故妊娠頭三個(gè)月相對(duì)安全。
A Effects (影響)of ACE and ACE inhibitors(抑制劑)
B Wide(廣泛的) use (使用)of ACE inhibitors
C How to deal with (處理,應(yīng)對(duì))high blood pressure (高血壓)in pregnant women
E Suggestions on (關(guān)于...的建議)stopping(停止) the use of ACE inhibitors
3. Paragraph 4
ACE inhibitors are often given to patients with diabetes. But diabetes during pregnancy can result in birth defects.5 So the study did not include any women known to be diabetic. ACE inhibitors suppress(抑制) a protein(蛋白質(zhì)) called angiotensin-converting enzyme(酶), or(即) ACE. This enzyme (酶)produces a chemical in the body that makes blood passages narrow. The drugs increase(增加) the flow (流動(dòng))of blood so pressure(血壓) is reduced(被減少).
3.A 這個(gè)段落的主題詞是ACE,因此A, B和E可能是答案。 現(xiàn)在可以利用排除法答題:假設(shè)B是答案, B中提到ACE抑制劑的廣泛使用, 則段落中應(yīng)該具體提到在哪些領(lǐng)域中使用的例子, 結(jié)果發(fā)現(xiàn)段落中根本沒(méi)有出現(xiàn)use, application, apply, function 等與使用或用途相關(guān)的詞, 因此B不是答案; 假設(shè)E是答案,則段落中應(yīng)該出現(xiàn)至少一條關(guān)于停止使用ACE抑制劑的建議, 既然上段已經(jīng)提到ACE的使用是相對(duì)安全的, 因此這個(gè)段落如果出現(xiàn)建議停止使用的內(nèi)容就不合理了,因此E不是答案, 因此答案只能使A。第四段說(shuō),ACE抑制劑可以抑制一種叫ACE的蛋白質(zhì),ACE可以使血管變窄,而ACE抑制劑則可增加血流使血壓下降。
B Wide(廣泛的) use (使用)of ACE inhibitors
C How to deal with (處理,應(yīng)對(duì))high blood pressure (高血壓)in pregnant women
E Suggestions on (關(guān)于...的建議)stopping(停止) the use of ACE inhibitors
4. Paragraph 5
New drugs are tested on pregnant animals to see if they might cause birth defects in humans. But experts say these tests are not always dependable. The United States Food and Drug Administration6 (美國(guó)食品藥品管理局)helped pay for the study. The F.D.A. says women who might become pregnant(懷孕的) should talk with(與...交談) their doctor about other ways to treat(治療) high blood pressure(高血壓).
4 解答完成句子題:
A that may cause our blood vessels to become more and more narrow
B for pregnant women to take during their last six months of pregnancies
C that their likelihood to suffer major problems is two times higher than other babies
D with their doctors(醫(yī)生) about how to treat(治療) their problems
E because diabetes during pregnancy may sometimes lead to birth defects
F though their mothers took ACE inhibitors during their first three months of pregnancies
被選項(xiàng)是不同的語(yǔ)法結(jié)構(gòu), 因此可能有些題能借助語(yǔ)法搭配結(jié)構(gòu)直接判斷答案。
5. FDA suggests(建議) that pregnant(懷孕的) women ith high blood pressure should consult(咨詢, 請(qǐng)教with) . 根據(jù)搭配結(jié)構(gòu)直接判斷D是答案。
5。D 本題答案存在于文章的最后一句?梢岳脝(wèn)題句中的特征詞作為答案線索在文章中找到答案相關(guān)句: The F.D.A. says women who might become pregnant(懷孕的) should talk with/consult with(向...請(qǐng)教) their doctor about other ways to treat(治療) high blood pressure(高血壓).
A that may cause our blood vessels(脈管) to become more and more narrow(狹窄的)
B for pregnant(懷孕的) women to take(服用) during their last six months of pregnancies(懷孕)
C that their likelihood to suffer major problems is two times higher than other babies
E because diabetes during pregnancy may sometimes lead to birth defects
F though their mothers took ACE inhibitors during their first three months of pregnancies
6. ACE inhibitors are not recommended(被推薦) .
6。B 利用問(wèn)題句中的特征詞ACE inhibitors作為答案線索, 在第二段第一句中找到答案相關(guān)句:Doctors have known (已經(jīng))for years that women should not take(服用) ACE inhibitors during the last six months of pregnancy(懷孕).
A that may cause our blood vessels to become more and more narrow
C that their likelihood to suffer major problems is two times higher than other babies
E because diabetes during pregnancy may sometimes lead to birth defects
F though(盡管) their mothers took ACE inhibitors during their first three months of pregnancies(懷孕)
7. Evidence(證據(jù)) showed(證明) only a small percentage of (一小部分的)babies suffered(遭受到) major disorders(紊亂) .
7. F 。 利用問(wèn)題句中的細(xì)節(jié)信息詞disorder 作為答案線索, 在文章中查找答案相關(guān)句:
Two hundred nine babies were born to (被...所生)women who took(服用)ACE inhibitors during the first three months of their pregnancies(懷孕). Eighteen of the babies, or(即) almost(差不多,幾乎) nine percent, had major disorders.
第三段后半部說(shuō)到,研究人員研究了大約30,000個(gè)嬰兒,其中209個(gè)嬰兒的母親在妊娠的頭三個(gè)月服用過(guò)ACE抑制劑,但只有18個(gè)嬰兒患有大病,大約占9%。
A that may cause our blood vessels(脈管) to become more and more narrow(狹窄的)
C that their likelihood to suffer major problems is two times higher than other babies
E because diabetes during pregnancy may sometimes lead to birth defects
8. ACE is a risk(風(fēng)險(xiǎn)) factor(因素) to our body .
8。A 利用問(wèn)題句中的特征詞ACE 作為答案線索,在第四段倒數(shù)第二句中找到答案相關(guān)句
ACE inhibitors suppress(抑制) a protein(蛋白質(zhì)) called angiotensin-converting enzyme, or ACE. This enzyme(酶) produces(產(chǎn)生) a chemical(化學(xué)物質(zhì)) in the body that makes blood passages(通道,段落) narrow(狹窄的).
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